The federal government instituted prohibition in 1916. Although considered a social experiment at the time it was met with varying degrees of resistance. Quebec refused to comply and was granted an exemption. In 1927 the experiment was deemed not only a failure but a disaster. The provinces quickly filled the vacuum left by the repeal of prohibition.
We are today faced with a federal government study group looking into legalizing marijuana. Headed by former Toronto police chief Bill Blair, it's tasked with determining how to control its sale, distribution and taxation but apparently is not considering individual community tolerances to the stuff.